Glucan Particles as a Carrier of Biological Active Substances

Authors

  • Z. Plavcová Department of Molecular Biology and Pharmaceutical Biotechnology, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno
  • D. Rotrekl Department of Molecular Biology and Pharmaceutical Biotechnology, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno
  • J. Hošek Department of Molecular Biology and Pharmaceutical Biotechnology, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno

Keywords:

β-glucans, glucan particles, vaccination, carrier

Abstract

Nowadays, there is a continuous need to find new types of the safe drugs. This review deals with various possibilities of application of glucan particles (GP), and emphasizes their advantages when used as carrier for oral vaccination. The trend in research is to develop and improve methods of oral vaccination, where the antigen can produce the required immunological responses. Currently, only few vaccines are approved for oral administration. Glucan particles can be used for the stimulation of both humoral and cellular immune response. Substances encapsulated into GP are protected against the harsh environment of the gastrointestinal tract. The particles can be used as a carrier of siRNA and also as a carrier of various kinds of substances like resveratrol.

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Published

2019-01-15

How to Cite

Plavcová, Z., Rotrekl, D., & Hošek, J. (2019). Glucan Particles as a Carrier of Biological Active Substances. Chemické Listy, 113(1), 35–41. Retrieved from http://www-.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/3263

Issue

Vol. 113 No. 1 (2019)

Section

Articles